开发和搭建针对临床医疗数据的挖掘方法和工具集,利用分布式计算和动态数据展示等技术,最终形成开源性、可线性扩展、高通用性、高吞吐和高可用的医疗健康大数据挖掘分析平台;研究建立基于隐私保护的数据共享和数据交换服务模式,建立数据共享平台。
DIALIGN-TX is freely available under the GNU Lesser General Public License (LGPL).
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DIALIGH
用于比对DNA、RNA或氨基酸序列数据
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ClustalW/X
Clustal Omega is the latest addition to the Clustal family. It offers a significant increase in...
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Clustal Omega
将测序的读序比对到基因组或转录组上
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TopHat
将测序的读序比对到基因组或转录组上
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STAR
将测序的读序比对到基因组或转录组上
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MapSplice
将测序的读序比对到基因组或转录组上
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Segemehl
T-Coffee is a multiple sequence alignment package. It can align Protein, DNA and RNA sequences. It is...
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T-Coffee
MUSCLE is one of the most widely-used methods in biology. On average, MUSCLE is cited by ten new papers ...
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MUSCLE
VCFtools用于处理VCF文件(比如千人基因组产生的数据),提供了简易可行的方法处理复杂的遗传变异数据。
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VCFtools
用于高通量测序数据处理的工具包,如读取,写入,编辑,建立索引,查看等
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GTOOL
用于将二代测序的DNA短序列定位到参考基因组上
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BWA
用于将二代测序的RNA短序列定位到参考基因组上。
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Bowtie2
用于高通量测序数据处理的工具包,如读取,写入,编辑,建立索引,查看等
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Samtools
用于高通量测序数据的处理,如去重复,再比对,碱基质量矫正,突变文件的分型等
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GATK
用于高通量测序数据索引的建立,方便大数据的处理。(Note: tabix and bgzip binaries are now part of the...
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bgzip_tabix
LiftOver 用于转换不同基因组装配(assemblies)的基因组坐标范围及注释文件
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LiftOver
Software for 3D facial image alignment
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Face Analysis
A software for biological network alignment
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BinAligner
An efficient tool for Molecular Interaction Maps Overlap
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MIMO
Software aligning two time series data of gene expression
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R package TimeShift
可用于查询基因组各个位点的注释信息(来源于1000 Genomes Project, Roadmap,ENCODE等数据库)
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HaploReg
用于基因注释
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ANNOVAR
A program which computes a phylogenetic super network from a collection of partial phylogenetic trees
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SuperQ
Epigenetic Variable Outliers for Risk Prediction Analysis
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EVORA
FEM can identify interactome hotspots of differential promoter methylation and differential
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FEM
Independent Surrogate Variable Analysis
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ISVA
A quartet based method to reconstruct phylogenetic networks
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Quarter-Net
A bioinformatics web app for identifying network-based biomarkers
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SurvNet
A software package for estimating phylogenetic networks based on quartets
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QNet
A new link between static and dynamic complex network analysis
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SPNConverter
An S-System Parameter Estimation Method for Biological Networks
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SPEM
This package predicts the gene-gene interaction network and identifies the direct transcriptional...
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NTW
Finding junction reads for circular intronic RNAs
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CIRCfinder
A Package for Elementary Analysis of SNP Data
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PEAS V1.0
Aanalyze splicing and gene expression based on RNA-seq data
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Splicing Analyzer by Java and R (SAJR)
Accurately detecting genome-wide nucleosome positions is important to understanding chromatin remodeling...
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iNPS
Predict transcription start sites from epigenetic and RNA-seq profiles
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TSS predictor
Predict regulatory pathway from weighted network
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eResponseNet
Predict regulatory Bayesian network from gene perturbation data
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DM_BN
Predict regulatory Bayesian network from heterogeneous data
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SeqSpider
Evaluate function association by significance of co-citation
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CoCiter
This manual describes how to use FastEPRR, an R package for estimating the population recombination rate
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FastEPRR
Denoising Algorithm using Relevance Network Topology to estimate signalling pathway activity
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DART
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